From Lewis Blevins, MD – Bilateral adrenalectomy has always been an option to treat hypercortisolism due to Cushing’s disease due to an ACTH-secreting pituitary tumors. It is not considered first line treatment as it is
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Understanding Food-Dependent Hypercortisolism
March 10, 2026
From the desk of Lewis Blevins, MD – I remember, in the mid-1990s, when a paper was published indicating that food dependent hypercortisolism was due aberrant GIP receptor expression on the adrenal glands. Eating activates
Connshing Syndrome: A 35-Year-Old Hunch, a Patient’s Instinct, and a Diagnosis That Changed Everything
February 27, 2026
From the desk of Lewis Blevins, MD, AWN cofounder – I have a vague recollection of considering the possibility of the coexistence of primary aldosteronism and hypercortisolism in adrenal hyperplasia during my fellowship in Endocrinology
What Are Hounsfield Units (HU) and Why Do They Matter for Adrenal Nodules?
February 27, 2026
Hounsfield Units (HU) are a measure of the radiodensity of different body tissues as determined by Computed Tomography (CT). This measure of the attenuation of an x-ray beam was named after Sir Godfrey Hounsfield.
The Adrenal Glands: A basic introduction.
February 27, 2026
From the desk of Lewis S. Blevins Jr. M.D. – The adrenals are paired glands, one on each side, that are located above the kidneys in the fatty tissues of the retroperitoneal space behind the
Dr. Lewis Blevins on Corcept’s CATALYST Study: The Cortisol-Diabetes Link
February 27, 2026
In this podcasts originally published in 2025, Dr. Lewis Blevins dives into the fascinating findings from a study by Corcept Therapeutics on the prevalence of hypercortisolism in people with type 2 diabetes. Results from this
When AI says it with confidence, but the sources say something else
February 17, 2026
Note form the editor: A while back, we published an article about the fundamental Catch-22 scenario of non-experts using AI to understand medical information. The core insight: to verify whether AI has correctly interpreted its
Hypercortisolism due to Adrenal Hyperplasia
January 27, 2026
From the desk of Lewis S. Blevins, Jr. MD – A 52-year-old man was referred to the pituitary clinic for further evaluation of hypercortisolism. Has had an unspecified weight gain and hypertension. His blood pressure
Schmidt’s syndrome
January 16, 2026
Schmidt’s syndrome is a condition described by the association of primary adrenal insufficiency, often referred to as Addisons disease, with autoimmune thyroid disease in the form of Hashimoto’s thyroiditis, with or without hypothyroidism, or Graves’ disease, with or without hyperthyroidism.
Regulation of Aldosterone Secretion
January 5, 2026
From the desk of Lewis S. Blevins, Jr. M.D. cofounder – The regulation of aldosterone secretion is rather complex. It is a beautiful system that involves multiple steps and organs. I will try to
Primary Pigmented Nodular Adrenocortical Disease
October 10, 2025
I first learned of this condition in 1990 during my fellowship training in endocrinology at The Johns Hopkins Hospital. I
Deep Fake or Deep Help? How AI Turned a Medical Paper into a Podcast (and why that matters)
October 8, 2025
An Opinion Editorial from Jorge D. Faccinetti – Co-founder and Chief Editor – In today’s publishing landscape, one thing is clear: artificial intelligence and machine learning are advancing at dizzying speeds. Keeping up with these developments and understanding their true impact on our work and lives has become increasingly challenging.
The Evolution of our Understanding of the Nuances of Pathologic Cortisol Secretion.
October 2, 2025
A few highlights: Cushing syndrome refers to the classical appearance of hypercortisolism as described by Dr. Harvey Cushing. Many patients with hypercortisolism or pathologic cortisol secretion do not appear cushingoid but instead have one or