Catching up with Dr. Mario Maldonado: milder hypercortisolism, AI, and what’s ahead

September 22, 2026

In this episode, Dr. Mario Maldonado from Recordati Rare Diseases discusses recent advances in endocrinology, focusing on hypercortisolism, diagnostic challenges, and innovative treatments. He shares insights from clinical studies and the future of AI in disease management.  We touched on the importance of increased awareness of milder forms of hypercortisolism, the challenges of diagnosing subtle endocrine disorders, and the critical impact of AI on data analysis and patient identification.

New osilodrostat data in adrenal Cushing’s

August 5, 2026

From Lewis Blevins, M.D. Medical Director of the California Center for Pituitary Disorders at UCSF and PWN co-founder – a summary of an important study by Dr. Marta Araujo-Castro and others (J Clin Endocrinol Metab 111:2180-2189, 2026) recently published a manuscript titled “International real-world study on osilodrostat efficacy and safety in adrenal Cushing syndrome.”

Five Percent Was the Guess. Twenty-Four Percent Was the Answer.

July 15, 2026

There is a particular kind of moment in medicine when a field discovers that one of its settled assumptions was simply wrong. It rarely arrives with drama. More often it arrives as a number on a slide. I ran into John Hilton, Vice President of Marketing at Corcept Therapeutics, on the floor at ENDO 2026 in Chicago and here’s our short chat.  We talked about where cortisol science is heading. We focused on the number nobody predicted.

Chronotherapy for hypercortisolism

June 2, 2026

Once-daily evening osilodrostat may restore circadian cortisol rhythm and improve sleep From Lewis S. Blevins Jr., MD – PWN co-founder and medical director of the California Center for Pituitary Disorders at UCSF – Chronotherapy is a