Pseudoscience in Endocrinology: The Adrenal Fatigue Problem
From the desk of Lewis Blevins, MD – There is no such thing as adrenal fatigue. Period. I’ve seen plenty of patients over my career who have been referred for this “condition.” It’s not a
Author: J D Faccinetti
Posts by J D Faccinetti
Understanding Food-Dependent Hypercortisolism
From the desk of Lewis Blevins, MD – I remember, in the mid-1990s, when a paper was published indicating that food dependent hypercortisolism was due aberrant GIP receptor expression on the adrenal glands. Eating activates
We dive into the new indications for Isturisa® with Recordati’s Dr. Mario Maldonado
This is a very informative discussion about the new indications of the Cushing’s Drug Isturisa® (osilodrostat) with Dr. Mario Maldonado, who heads global development for endocrinology at Recordati Rare Diseases.
Connshing Syndrome: A 35-Year-Old Hunch, a Patient’s Instinct, and a Diagnosis That Changed Everything
From the desk of Lewis Blevins, MD, AWN cofounder – I have a vague recollection of considering the possibility of the coexistence of primary aldosteronism and hypercortisolism in adrenal hyperplasia during my fellowship in Endocrinology
What Are Hounsfield Units (HU) and Why Do They Matter for Adrenal Nodules?
Hounsfield Units (HU) are a measure of the radiodensity of different body tissues as determined by Computed Tomography (CT). This measure of the attenuation of an x-ray beam was named after Sir Godfrey Hounsfield.
The Adrenal Glands: A basic introduction.
From the desk of Lewis S. Blevins Jr. M.D. – The adrenals are paired glands, one on each side, that are located above the kidneys in the fatty tissues of the retroperitoneal space behind the
Dr. Lewis Blevins on Corcept’s CATALYST Study: The Cortisol-Diabetes Link
In this podcasts originally published in 2025, Dr. Lewis Blevins dives into the fascinating findings from a study by Corcept Therapeutics on the prevalence of hypercortisolism in people with type 2 diabetes. Results from this
When AI says it with confidence, but the sources say something else
Note form the editor: A while back, we published an article about the fundamental Catch-22 scenario of non-experts using AI to understand medical information. The core insight: to verify whether AI has correctly interpreted its
Learn about Catecholamines
Catecholamines are a group of chemicals that act as neurotransmitters and hormones in the body. The principal ones include epinephrine, norepinephrine, and dopamine. They are produced in the brain, the sympathetic component of the autonomic
The Cushing Syndrome Conundrum: Diagnosing and Managing a Silent Driver of Hypertension
In this recent Medscape InDiscussion podcast Dr. Marwah Abdalla welcomes PWN’s Dr. Lewis Blevins to talk about secondary hypertension. This episode focuses on Cushing syndrome, an often overlooked cause of secondary hypertension. We’ll discuss why
When ‘Normal’ Isn’t Normal: The Problem with Adrenal Hyperplasia Diagnosis
Hyperplasia is a term that implies an increase in the number of normal cells in a gland or other tissue. Sometimes the cells themselves are also enlarged, or hypertrophic. Tissues can be hypertrophic without being
From Discovery to Delivery: Crinetics Co-Founders on the Journey to Bring new drugs to Patients
In today’s podcast, Crinetics co-founders Dr. Scott Struthers and Dr. Steve Betz share their views and experiences in drug discovery and development, revealing what it really takes to bring a new medication from concept to patients.